Objective To investigate subjective and objective financial burden and its correlation with health-related quality of life（HRQOL） among pulmonary artery hypertension（PAH） patients. Methods From February to September 2022，we conducted convenience sampling method to select PAH patients who were followed up in a tertiary hospital，using General Information Questionnaire，Comprehensive Score for Financial Toxicity Functional Assessment of Chronic Illness Therapy（COST），and PAH-specific HRQOL measurement（EmpPHasis-10）. Logistic regression model was used to analyze the independent influencing factors. Results 152 PAH patients were included，and 123（80.9%） patients experienced financial burden，and the mean score of subjective financial burden was 16.22±10.19. The multivariate linear regression analysis showed that pulmonary artery systolic pressure（PASP），6 minute walk distance（6MWD），social-economic status，catastrophic health care expenditures，and cost-related medication nonadherence（CRNA） were influencing factors of financial burden，which accounted 42.9% of the total variation. Financial burden was correlated with EmpPHasis-10（P<0.05）. Conclusion The subjective and objective financial burden of PAH patients were common，and the HRQOL of patients with high financial burden level was seriously impaired. Medical staff should pay attention to and comprehensively screen the financial burden to prevent patients from becoming poor due to disease in the stage of disease management，so as to reduce the impact of financial burden on patients’ prognosis.

Objective To retrieve and evaluate the available evidence on glycemic self-management education and support for patients with gestational diabetes mellitus，and to summarize the best evidence to provide references for clinical practice. Methods According to the top-down principle of the evidence-based resource 6S model，computer decision support systems，guideline websites，association official websites and databases were systematically searched for the relevant evidence on the glycemic self-management education and support for patients with gestational diabetes mellitus，including guidelines，expert consensuses，evidence summaries，best practice and systematic reviews. The search time limit was from the establishment of databases to September 25th 2022. 2 researchers evaluated the quality of the literature，extracted and summarized the evidence according to the subject. Results A total of 16 articles were included，including 6 guidelines，1 expert consensus，4 evidence summaries and 5 systematic reviews. 18 pieces of best evidence were summarized from 4 aspects，including the goals and principles of glycemic self-management，assessment，self-management education and self-management support. Conclusion This study summarized the best evidence of glycemic self-management education and support for patients with gestational diabetes mellitus and formed specific recommendations. The best evidence summarized in this study is meaningful for nurses providing evidence to establish individualized glycemic self-management programs for patients with gestational diabetes mellitus.

Objective To explore the barriers in the clinical use of evidence-based deep vein thrombosis prevention after joint replacement,and to provide bases for clinical measures. Methods The interview outline was developed based on the Theoretical Domains Framework（TDF） from July to August 2020. Totally 16 nurses working in the department of orthopedic at a tertiary A hospital in Beijing were selected for semi-structured interviews by convenient sampling,and the content analysis was conducted based on the results. The content of the transcribed text is analyzed,and specific topics and codes are classified according to the relevant fields of TDF. Results In clinical practice,the department has used the HIS system to assess DVT risks,but the nurses do not have a good grasp of the assessment scale,and the case information need to be retrieved,which has caused certain obstacles to the development of the assessment work. Nurses have the awareness to carry out health education and nursing prevention,but due to the lack of auxiliary tools,it is difficult to attract patients’ attention,and thus they lose the will to act,and hold doubts about the prevention effects. Nurses master health education related content and can implement physical and drug prevention,and the department has carried out prevention effect evaluation. However,due to the lack of relevant procedures,there are differences in behaviors among nurses. Combined with TDF,the above obstacles are classified into 5 domains：knowledge,environmental factor,motivation and target,result expectation,and code of conduct. Conclusion There is a variety of obstacles that affect the prevention of deep vein thrombosis after joint replacement in clinical application. It is necessary for the department to carry out the reform of evidence-based nursing practice on the basis of obstacles and promote the clinical application of the best evidence for the prevention of deep vein thrombosis after joint replacement.

Objective To explore the risk factors and safety infusion protocol of peripheral vasoactive medication. Methods 5 guideline websites and 7 databases were searched from their inception until March 7,2021. We qualitatively described the characteristics of complications,risk factors, and safety infusion protocols of peripheral vasoactive medication. Results A total of 14 articles were incorporated,including 2 guidelines,4 systematic reviews,and 8 original articles. It shows that the safety of peripheral vasoactive medication is affected by drug,patient,and infusion protocol. A guideline and 8 original articles provide the safety infusion protocol,including infusion site,infusion technique,infusion duration,frequency of observation,and management of complications. Conclusion Short-term use of peripheral vasoactive medication is safe and feasible under the whole-process risk assessment and protective strategy.

Objective To understand the work content of deep vein thrombosis （DVT） preventive care after hip and knee replacement,and to clarify the gap between the current practice and the best evidence. Methods From June to October 2019,we used the field research methods to conduct a 5-month participatory observation about the nursing work in the joint surgery ward in a level A tertiary hospital in Beijing. We used the three-level coding method of qualitative research to conduct field notes analysis. Results Through the care experience of participating in 391 cases of preventing DVT after hip and knee replacement,this study clarified the work content of preventive care,and extracted 4 work content themes,namely Education,Enforcement,Evaluation and E-recording,which fit with the best evidence. However,there is a partial gap between the implementation effect and the best evidence,and it still needs further development in enhancing health education and early activities promotion. Conclusion Through the field research,we have learned about the nursing work content in preventing DVT after hip and knee replacement,and the gap between the present situation and the best evidence and the possible reasons. Carrying out evidence-based nursing research and constructing scientific,normative and clinically feasible standardized preventive nursing plans are the best ways to prevent DVT after hip and knee replacement.